We’ve all experienced it. When we’re engaged in something that interests us, we can go for a long time without thinking of sleep. The opposite is true of things that don’t interest us. With those activities, frequently we start to nod off. But, why is that?
The brain mechanisms governing the regulation of sleep by cognitive and emotional factors are not well understood. But, a new study finds that a part of the brain that is associated with motivation and pleasure – the nucleus accumbens – also can produce sleep. The new findings may explain why we have the tendency to fall asleep in the absence of motivating stimuli, i.e., when bored.
Researchers at the University of Tsukuba’s International Institute for Integrative Sleep Medicine (WPI-IIIS) and Fudan University’s Department of Pharmacology in the School of Basic Medical Sciences used techniques to remotely control the activities of nucleus accumbens neurons and the behaviors they mediate. As a result, the Japanese-Chinese team discovered that nucleus accumbens neurons have an extremely strong ability to induce sleep.
Adenosine has long been known to represent a state of relative energy deficiency and to induce sleep via adenosine receptors. A specific subtype of adenosine receptors, the A2A receptors, are densely expressed in the nucleus accumbens. Caffeine, the most widely consumed psychostimulant in the world, produces its arousal effect also in the nucleus accumbens by blocking A2A receptors.
Compounds that activate A2A receptors in the nucleus accumbens may open safe therapeutic avenues for treating insomnia, which is one of the most common sleep problems, with an estimated prevalence of 10-15% in the general population and 30-60% in the older population.
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