Can staying up late make you fat? A growing body of research has suggested that poor sleep quality is linked to an increased risk of obesity by deregulating appetite, which in turn leads to more calorie consumption.
But a new study published this week found that the direction of this reaction might actually be flipped: It’s not the sleep loss that leads to obesity, but rather that excess weight can cause poor sleep, according to researchers from the University of Pennsylvania’s Perelman School of Medicine and the University of Nevada, Reno, who discovered their findings in the microscopic worm Caenorhabditis elegans (C. elegans).
“We think that sleep is a function of the body trying to conserve energy in a setting where energetic levels are going down. Our findings suggest that if you were to fast for a day, we would predict you might get sleepy because your energetic stores would be depleted,” said study co-author David Raizen, MD, PhD, an associate professor of Neurology and member of the Chronobiology and Sleep Institute at Penn.
Raizen emphasized that while these findings in worms may not translate directly to humans, C. elegans offer a surprisingly good model for studying mammalian slumber. Like all other animals that have nervous systems, they need sleep. But unlike humans, who have complex neural circuitry and are difficult to study, a C. elegans has only 302 neurons — one of which scientists know for certain is a sleep regulator.
In humans, acute sleep disruption can result in increased appetite and insulin resistance, and people who chronically get fewer than six hours of sleep per night are more likely be obese and diabetic. Moreover, starvation in humans, rats, fruit flies, and worms has been shown to affect sleep, indicating that it is regulated, at least in part, by nutrient availability. However, the ways in which sleeping and eating work in tandem has remained unclear.
“We wanted to know, what is sleep actually doing? Short sleep and other chronic conditions, like diabetes, are linked, but it’s just an association. It’s not clear if short sleep is causing the propensity for obesity, or that the obesity, perhaps, causes the propensity for short sleep,” said study co-author Alexander van der Linden, PhD, an associate professor of Biology at the University of Nevada, Reno.
To study the association between metabolism and sleep, the researchers genetically modified C. elegans to “turn off” a neuron that controls sleep. These worms could still eat, breathe, and reproduce, but they lost their ability to sleep. With this neuron turned off, the researchers saw a severe drop in adenosine triphosphate (ATP) levels, which is the body’s energy currency.
“That suggests that sleep is an attempt to conserve energy; it’s not actually causing the loss of energy,” Raizen explained. “There is a common, over-arching sentiment in the sleep field that sleep is all about the brain, or the nerve cells, and our work suggests that this isn’t necessarily true. There is some complex interaction between the brain and the rest of the body that connects to sleep regulation.”